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赵春建

发布时间:2019-11-13文章来源: 浏览次数:


一、基本信息

赵春建,1977年生,教授,博士生导师。现任药学一级学科带头人、生药学方向带头人,森林植物生态学教育部重点实验室副主任,林业生物制剂教育部工程研究中心副主任,黑龙江省林源活性物质生态利用重点实验室副主任,东北林业大学植物药工程研究中心主任。任黑龙江省植物学会副理事长,黑龙江省生态学会常务理事,《Frontiers in Nutrition》编委,《Forests》和《Separations》专刊客座主编。联系方式:zcjsj@163.com

主要从事药用植物资源目的生物活性物质定向诱导、分离纯化、质量控制和植物种间化学关系等方面的研究与开发工作。主持国家重点研发计划课题、国家自然科学基金项目、林业公益性行业科研专项课题、“十二五”国家科技计划课题、中国博士后科学基金、教育部博士点基金、黑龙江省自然科学基金等项目10余项。获得授权专利18项,主编专著2部,发表SCI学术论文50余篇。先后荣获国家科技进步二等奖、国家技术发明二等奖各1项,省部级奖励6项。

二、学习经历:

· 2003.9–2006.6, 东北林业大学, 植物学专业, 博士

· 2000.9–2003.6, 东北林业大学, 植物学专业, 硕士

· 1996.9–2000.7, 东北林业大学, 林学专业, 学士

三、工作经历:

· 2019.7-, 东北林业大学, 金沙首页登录, 教授

· 2016.9-2019.07, 东北林业大学, 森林植物生态学教育部重点实验室, 教授

· 2015.8-2016.8, 美国马萨诸塞大学达特茅斯分校, 化学与生物化学系, 访问学者

· 2012.09-2015.06, 中国农业大学, 生态学专业, 博士后

· 2008.11-2011.05, 浙江海正药业股份有限公司, 博士后

· 2008.9-2016.8, 东北林业大学, 森林植物生态学教育部重点实验室, 副教授

· 2006.9-2008.8, 东北林业大学, 森林植物生态学教育部重点实验室, 讲师

· 2003.6-2006.8, 东北林业大学, 森林植物生态学教育部重点实验室, 助教

四、所在学科

药学(硕士点)/植物学(博士点)

五、研究方向:

1. 天然药物化学

2. 化学生态学

3. 植物资源学

六、近年科研项目:

1. 科技部/国家重点研发计划课题:红豆杉等高效培育与利用技术研究 (2017YFD0601306), 2017年至2020, 424.00万元, 主持人。

2. 国家自然科学基金/面上项目:Taxanes介导的喜树-南方红豆杉人工混交林种间促进作用研究 (31870609), 2019年至2022, 59.00万元, 主持人。

3. 中央高校基本科研业务费专项资金项目:特色森林资源高效培育与精深加工利用关键技术研究(2572019CZ01), 2019年至2022, 50.00万元, 主持人。

4. 黑龙江省科技厅/国家重点研发项目省级资金资助项目:红豆杉等高效培育与利用技术(GX18B037), 2017年至2020, 20.00万元, 主持人。

5. 国家自然科学基金/青年科学基金项目:南方红豆杉根系分泌物促进喜树生长和积累的化感作用机制 (31200478), 2013年至2015, 22.00万元, 主持人。

6. 国家林业局/国家级林业推广项目:水溶性喜树碱生产关键技术推广 (2014-35), 2014年至2017, 50.00万元, 主持人。

7. 科技部/国家科技支撑计划课题子课题:喜树碱提取工艺研究 (2012BAD21B050102), 2012年至2015, 20.00万元, 主持人。

8. 国家林业局/林业公益性科研专项课题子课题:京尼平水溶性粉体制备研究 (2012046010103), 2012年至2015, 20.00万元, 主持人。

9. 国家林业局/林业公益性科研专项课题子课题:纤维基乙醇汽油开发研究 (20130460103), 2013年至2016, 49.00万元, 主持人。

10. 中央高校基本科研业务费专项资金项目:东北特色浆果资源精深加工利用技术研究(2572015EA04), 2015年至2018, 40万元, 主持人

11. 中国博士后科学基金:小麦化感品种对伴生苘麻的化学识别与响应机制(2013M530773, 2013年至2014, 5.00, 主持人。

12. 黑龙江省科技厅/自然科学基金项目:环境因子对烟草茄尼醇代谢的调控机制 (C201412), 2014年至2017, 6.00万元, 主持人。

13. 高等学校博士学科点专项科研基金课题:南方红豆杉根系化感物质促进喜树幼苗生长和喜树碱积累的机制 (20120062120014 ), 2013年至2015, 4.00万元, 主持人

14. 黑龙江省博士后科研启动金资助:马铃薯茎叶高效分离茄尼醇的研究(LBH-Q11177), 2011年至2014, 5.00万元, 主持人

15. 东北林业大学青年拔尖人才支持计划(PYTT-1213-06)2013年至2014, 4.00万元, 主持人

16. 哈尔滨市科学技术局项目:茄尼醇和烟碱代谢调控及高效分离技术(2006RFQXN003), 20061-20081, 2.8万元, 主持人

17. 浙江海正药业股份有限公司横向项目:茄尼醇的高效制备工艺研究(432011), 20041-20101, 40万元, 主持人

七、近年发表的主要学术论文

1. Chunying Li*, Changyin Feng, Mengfei Tian, Xianming Meng, Chunjian Zhao. A Novel approach for echinacoside and acteoside extraction from Cistanche deserticola Y. C. Ma using an aqueous system containing ionic liquid surfactants. Sustainable Chemistry and Pharmacy, 2022, 26: 100644.(SCI)

2. Chunying Li, Xianming Meng, Mengfei Tian, Shen Li, Yao Tian, Chunjian Zhao, Yujie Fu. A novel method to extract juglone from Juglans mandshurica waste branches using a water-in-oil microemulsion. Waste and Biomass Valorization, 2022, 13: 1547–1563.(SCI)

3. Sen shi, YinXiang Gao, Chunying Li *, Jingjing Zhang, Jiajing Guan, Chunjian Zhao, Yujie Fu. Allelopathy of Taxus chinensis var. mairei on Camptotheca acuminata seedling growth and identification of the active principles. Journal of Plant Interactions, 2022, 17: 33–42.(SCI)

4. Lixin Wei, Xin Li, Weiran Su, Chunjian Zhao*, Aoqi Wang, Lingling Dong, Mengfei Tian, Chunying Li*. A novel approach for synchronous transformation and extraction of psoralen from fig (Ficus carica L.) leaves based on polarity of different macroporous adsorption resins. Chemical Engineering Research and Design, 2022, 178: 148-156.(SCI)

5. Chunying Li, Fang Nie, Changyin Feng, Mengfei Tian, Meiting Yu, Chunjian Zhao*, Yujie Fu*. Magnetic dual-template molecularly imprinted polymers for separation and enrichment of echinacoside and acteoside from Cistanche deserticola Y. C. Ma. Chemical Engineering Research and Design, 2022, 182: 719-732.(SCI)

6. Bin Qiao, Chunying Li*, Chunyu Liang, Xin Li, Mengfei Tian, Qianqian Li, Chunjian Zhao*, Yujie Fu*. Determination of phenolic acids in Rehmannia glutinosa rhizosphere using a new method of microdialysis-HPLC. South African Journal of Botany, 2022, 148: 387-395.(SCI)

7. Mengfei Tian, Qianqian Li, Wenyan Zhao, Bin Qiao, Sen Shi, Meiting Yu, Xin Li, Chunying Li*, Chunjian Zhao*. Potential allelopathic interference of Abutilon theophrasti Medik. powder/extract on seed germination, seedling growth and root system activity of maize, wheat and soybean. Agronomy, 2022, 12(4):844.(SCI)

8. Chunjian Zhao, Jiabo Cheng, Chunying Li*, Shen Li, Yao Tian, Tingting Wang, Yujie Fu. Quality evaluation of Acanthopanax senticosus via quantitative analysis of multiple components by single marker and multivariate data analysis. Journal of Pharmaceutical and Biomedical Analysis, 2021;201: 114090.(SCI)

9. Chunying Li, Meiting Yu, Shen Li, Xue Yang, Bin Qiao, Sen Shi, Chunjian Zhao, Yujie Fu. Valorization of Fig (Ficus carica Linn.) waste leaves: HPLC-QTOF-MS/MS-DPPH system for online screening and identification of antioxidant compounds. Plants, 2021, 10, 2532.(SCI)

10. Chunjian Zhao, Xin Li, Chunying Li*, Shen Li, Yao Tian, Tingting Wang, Yujie Fu. Ingenious application of ethylenediaminetetraacetic acid disodium to improve the extraction yield of psoralen in fig (Ficus carica L.) leaves. Natural Product Research, 2021, 1980792.(SCI)

11. Chunying Li, Xue Yang, Yao Tian, Meiting Yu, Sen Shi, Bin Qiao, Chunjian Zhao, Liang Mao. The effects of fig tree (Ficus carica L.) leaf aqueous extract on seed germination and seedling growth of three medicinal plants. Agronomy, 2021;11: 2564.(SCI)

12. Xue Yang, Yuzheng Li, Chunying Li*, Qianqian Li, Bin Qiao, Sen Shi, Chunjian Zhao. Enhancement of interplanting of Ficus carica L. with Taxus cuspidata Sieb. et Zucc. on growth of two plants. Agriculture, 2021;11: 1276.(SCI)

13. Chunjian Zhao, Shen Li, Chunying Li*, Tingting Wang, Yao Tian, Xin Li, Yujie Fu. Ultrasonic enzyme co-assisted aqueous two-phase extraction and identification of flavonoid compounds from Fig (Ficus carica Linn.) leaves using UPLC-QTOF-MS/MS. Appled Sciences, 2021, 11, 7718.(SCI)

14. Chunying Li, Yao Tian, Shen Li, Tingting Wang, Xin Li, Chunjian Zhao, Yujie Fu. Application of fingerprint combined with quantitative analysis and multivariate chemometric methods in quality evaluation of dandelion (Taraxacum mongolicum). Royal Society Open Science. 2021, 8, 210614.(SCI)

15. Chunjian Zhao, Xueting Ren, Chunying Li*, Hongwei Jiang, Jiajing Guan, Weiran Su, Yuzheng Li, Yao Tian, Tingting Wang and Shen Li. Coupling ultrasound with heat-reflux to improve the extraction of quercetin, kaempferol, ginkgetin and sciadopitysin from Mairei yew leaves, Appl. Sci.2019, 9(4), 795.(SCI)

16. Haiyao Sun, Chunying Li, Yujiao Ni, Liping Yao, Hongwei Jiang, Xueting Ren, Yujie Fu, Chunjian Zhao*. Ultrasonic/microwave-assisted extraction of polysaccharides from Camptotheca acuminata fruits and its antitumor activity. Carbohydrate Polymers, 2019, 206: 557–564. (SCI)

17. Chunying Li, Jingjing Zhang, Chunjian Zhao*, Wenyan Zhao, Lei Yang, Hongwei Jiang, Xueting Ren, Weiran Sun, Yuzheng Li, Jiajing Guan. Separation of the main flavonoids and essential oil from seabuckthorn leaves by ultrasonic/microwave-assisted simultaneous distillation extraction. Royal Society open science, 2018, 5(7): 180133.(SCI)

18. Chunying Li, Yukun, Zhang, Chunjian Zhao*, Yujiao Ni, Kaiting Wang, Jingjing Zhang, Wenyan Zhao. Ultrasonic assisted-reflux synergistic extraction of camptothecin and betulinic acid from Camptotheca acuminata Decne. fruits. Molecules, 2017, 22(7): 1076.(SCI)

19. Chunjian Zhao, Xin He, Chunying Li*, Lei Yang , Yujie Fu, Kaiting Wang , Yukun Zhang, Yujiao Ni. A microwave-assisted simultaneous distillation and extraction method for the separation of polysaccharides and essential oil from the leaves of Taxus chinensis var. mairei. Applied Sciences, 2016, 6: app6020019. (SCI)

20. Chunjian Zhao, Yukun Zhang, Chunying Li*, Xin He, Lei Yang , Yujie Fu, Jingjing Zhang, Wenyan Zhao, Yuangang Zu.. Development of an ionic liquid-based ultrasonic/microwave-assisted simultaneous distillation and extraction method for separation of camptothecin, 10-hydroxycamptothecin, vincoside-lactam, and essential oils from the fruits of Camptotheca acuminata Decne. Applied Sciences, 2016, 6(10): 293.(SCI)

21. Chunjian Zhao, Zhao Li, Chunying Li*, Lei Yang, Liping Yao, Yujie Fu, Xin He, Kunming Shi, Zhicheng Lu. Optimized extraction of polysaccharides from Taxus chinensis var. mairei fruits and its antitumor activity. International Journal of Biological Macromolecules, 2015, 75: 192-198. (SCI)

22. Chunying Li, Zhicheng Lu, Chunjian Zhao*, Lei Yang, Yujie Fu, Kunming Shi, Xin He, Zhao Li, Yuangang Zu. Ionic-liquid-based ultrasound/microwave-assisted extraction of 2, 4-dihydroxy-7-methoxy-1, 4-benzoxazin-3-one and 6-methoxy-benzoxazolin- 2-one from maize (Zea mays L.) seedlings. Journal of Separation Science, 2015, 38(2):291-300.(SCI)

23. Chunjian Zhao, Deman Liu, Chunying Li, Yujie Fu, Lei Yang, Yuangang Zu. Separation of pinostrobin from pigeon pea [Cajanus cajan (L) Millsp.] leaf extract using a cation exchange resin for catalytic transformation combined with a polyamide resin. Separation and Purification Technology, 2014, 133: 168-175. (SCI)

24. Chunjian Zhao, Shuaihua Liu, Chunying Li, Lei Yang, Yuangang Zu. In vitro evaluation of the antiviral activity of the synthetic epigallocatechin gallate analog-epigallocatechin gallate (EGCG) palmitate against porcine reproductive and respiratory syndrome virus. Viruses-Basel, 2014, 6(2): 938-950. (SCI)

25. Chunjian Zhao, ChunyingLi, Shuaihua Liu, Lei Yang. The galloyl catechins contributing to main antioxidant capacity of tea made from Camellia sinensis in China. The Scientific World Journal, 2014, Article ID: 863984. (SCI)

26. Chunjian Zhao, Zhicheng Lu, Chunying Li, Xin He, Zhao Li, Kunming Shi, Lei Yang, Yujie Fu, Yuangang Zu. Optimization of ionic liquid based simultaneous ultrasonic- and microwave-assisted extraction of rutin and quercetin from leaves of velvetleaf (Abutilon theophrasti) by response surface methodology. The Scientific World Journal, 2014, Article ID: 283024. (SCI)

27. Chunjian Zhao, Lei Wang, Yuangang Zu, Chunying Li, Shuaihua Liu, Lei Yang, Xiuhua Zhao, Baishi Zu. Micronization of Ginkgo biloba extract using supercritical antisolvent process. Powder Technology, 2011, 209(1-3), 73-80. (SCI)

28. Chunjian Zhao, Chunying Li, Lei Wang, Yuangang Zu, Lei Yang. Determination of Camptothecin and 10-Hydroxycamptothecin in Camptotheca acuminata by LC-ESI-MS/MS. Analytical Letters, 2010, 43(17): 2681-2693. (SCI)

29. Chunjian Zhao, Yuangang Zu, Chunying Li. Extraction of solanesol from tobacco (Nicotiana tobaccum L. leaves by bubble column. Chemical Engineering and Processing: Process Intensification, 2009, 48(1): 203-208. (SCI)

30. Chunjian Zhao, Chunying Li, Yuangang Zu. Rapid and quantitative determination of solanesol in Nicotiana tabacum by liquid chromatography–tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis, 2007, 44(1): 35-40.(SCI)

31. ZHAO Chun-jian, ZU Yuan-gang, LI Chun-ying, TIAN Cheng-yu. Distribution of solanesol in Nicotiana tabacum. Journal of Forestry Research, 2007, 18(1):69-72.

32. Ming-Hui Duan, Meng Luo, Chun-Jian Zhao, Wei Wang, Yuan-Gang Zu, Dong-Yang Zhang, Xiao-hui Yao, Yu-Jie Fu. Ionic liquid-based negative pressure cavitation-assisted extraction of three main flavonoids from the pigeonpea roots and its pilot-scale application. Separation and Purification Technology, 2013, 107: 26-36. (SCI)

33. Ji Li, Meng Luo, Chun-Jian Zhao, Chun-Ying Li, Wei Wang, Yuan-Gang Zu, Yu-Jie Fu. Oil removal from water with yellow horn shell residues treated by ionic liquid. Bioresource Technology, 2013, 128:673-678. (SCI)

34. Lei Yang, Chunjian Zhao, Chunying Li, Jiahui Li, Xiaojuan Li, Yuangang Zu.Separation by Macroporous Resins of 10-Hydroxycamptothecin from the Remainder Extracts in the Production of Camptothecin. Adsorption science and technology, 2009, 27(2) :117-134. (SCI)

35. Yuangang Zu, Chunjian Zhao, Chunying Li, Lin Zhang. A rapid and sensitive LC-MS-MS method for determination of coenzyme Q10 in tobacco (Nicotiana tabacum L.) leaves. Journal of Separation Science, 2006, 29, 1607-1612. (SCI)

36. Zuofu Wei, Meng Luo, Chunjian Zhao, Wei Wang, Lin Zhang, Yuangang Zu, Chunying Li, Tingting Li, Yujie Fu. An efficient preparative procedure for main flavone aglycones from Equisetum palustre L. using macroporous resin followed by gel resin flash chromatography. Separation and Purification Technology, 2013, 118(30): 680-689 (SCI).

37. Shuang Jin, Meng Luo, Wei Wang, Chun-jian Zhao, Cheng-bo Gu, Chun-ying Li, Yuan-gang Zu, Yu-jie Fu, Yue Guan . Biotransformation of polydatin to resveratrol in Polygonum cuspidatum roots by highly immobilized edible Aspergillus niger and Yeast, Bioresource Technology, 2013, 136: 766-770 (SCI)

38. Xue-Jin Qu, Yu-Jie Fu, Meng Luo, Chun-Jian Zhao, Yuan-Gang Zu, Chun-Ying Li, Wei Wang, Ji Li, Zuo-Fu Wei. Acidic pH based microwave-assisted aqueous extraction of seed oil from yellow horn (Xanthoceras sorbifolia Bunge.) Industrial Crops and Products, 2013, 43:420-426(SCI)

39. Dong-Yang Zhang, Meng Luo, Wei Wang, Chun-Jian Zhao, Cheng-Bo Gu, Yuan-Gang Zu, Yu-Jie Fu, Xiao-Hui Yao, Ming-Hui Duan. Variation of active constituents and antioxidant activity in pyrola [P. Incarnata Fisch.] from different sites in Northeast China. Food Chemistry, 2013, 141(3): 2213-2219(SCI)

40. Lei Yang, Zhen Sun, Yuangang Zu , Chunjian Zhao, Xiaowei Sun, Zhonghua Zhang, Lin Zhang. Physicochemical properties and oral bioavailability of ursolic acid nanoparticles using supercritical anti-solvent (SAS) process. Food Chemistry 132 (2012) 319–325

41. Cai-Yun Chen, Yuan-Gang Zu, Yu-Jie Fu, Meng Luo, Chun-Jian Zhao, Wei Wang, Bao-Shan Zhao, Ji Li, Thomas Efferth. Preparation and antioxidant activity of Radix Astragali residues extracts rich in calycosin and formononetin. Biochemical Engineering Journal, 2011, 56(1–2): 84-93(SCI)

42. Yuangang Zu, Chunying Li, Yujie Fu, Chunjian Zhao. Simultaneous determination of catechin, rutin, quercetin, kaempferol and isorhamnetin in the extract of sea buckthorn (Hippophae rhamnoides L.) leaves by RP-HPLC with DAD. Journal of Pharmaceutical and Biomedical Analysis. 2006, 41(3):714–719. (SCI)

43. Ye Liu, Lei Yang, Yuangang Zu, Chunjian Zhao, Lin Zhang, Ying Zhang, Zhonghua Zhang, Wenjie Wang. Development of an ionic liquid-based microwave-assisted method for simultaneous extraction and distillation for determination of proanthocyanidins and essential oil in Cortex cinnamomi Food Chemistry, 2012, 135(4): 2514-2521(SCI)

44. Jiao Jiao, Qing-Yan Gai, Meng Luo, Wei Wang, Cheng-Bo Gu, Chun-Jian Zhao, Yuan-Gang Zu, Fu-Yao Wei, Yu-Jie Fu. Comparison of main bioactive compounds in tea infusions with different seasonal Forsythia suspensa leaves by liquid chromatography–tandem mass spectrometry and evaluation of antioxidant activity Food Research International, 2013, 53(2): 857-863(SCI)

八、代表著作

1. 付玉杰, 顾成波, 赵春建, 张谡. 木豆资源深加工利用技术, 科学出版社, 2021

2. 赵春建, 路祺, 王洪政, 孟祥东, 林源活性物质分离技术, 科学出版社, 2015

3. 赵春建, 李春英, 董凤丽, 沙棘生物活性物质综合利用, 黑龙江科技出版社, 2013

4. 祖元刚, 赵春建, 李春英, 杨磊, 付玉杰, 烟䓍中的茄尼醇和辅酶Q10, 科学出版社, 2008

5. 聂绍荃主编, 赵春建参编, 黑龙江省植物资源志, 东北林业大学出版社, 2003

九、科研获奖:

1. 特色林药提取物高效分离关键技术与推广示范, 黑龙江省科学技术奖二等奖(发明), 2020, 第二完成人

2. 木豆资源功能活性成分高值化加工利用关键技术及产业化应用, 梁希林业科学技术二等奖, 2017, 第三完成人

3. 功能森林化学成分高效分离理论与方法的创新研究, 黑龙江省自然科学二等奖, 2014, 第三完成人

4. 喜树定向培育及喜树碱衍生物水溶性制备工艺创新, 第五届梁希林业科学技术奖, 2013, 第三完成人

5. 茄尼醇高效提取纯化生产新工艺, 教育部提名技术发明奖一等奖, 2006, 第四完成人

6. 茄尼醇高效提取纯化生产新工艺,国家技术发明奖二等奖,2006,第四完成人

7. 甘草多种有效成分高效提取纯化新工艺, 教育部提名国家科学技术进步奖二等奖, 2005, 第五完成人

8. 喜树碱衍生物高效提取技术研究, 国家科学技术进步奖二等奖, 2004, 第五完成人

十、获得授权专利

1. 赵春建, 李春英, 任雪婷, 付玉杰, 姜宏伟, 赵文燕, 苏伟然, 张晶晶, 关佳晶, 李玉正. 一种促进幼龄红豆杉生长的方法(发明专利), 专利号:ZL201810714923.1, 2020年授权.

2. Chunjian Zhao, Chunying Li, Yujie Fu, Hongwei Jiang, Wenyan Zhao, Weiran Su, Jingjing Zhang, Jiajing Guan, Yuzheng Li, Xueting Ren. Method for facilitating increase of content of taxane components in branches and leaves of Chinese Yew. AU2020101356, 2020年授权.

3. 赵春建, 李春英, 付玉杰, 祖元刚.提高喜树种子中10-甲氧基喜树碱含量的方法(发明专利), 专利号:ZL 201410122210.8, 2015年授权.

4. 赵春建, 李春英, 祖元刚.一种喜树种子发芽方法(发明专利), 专利号:ZL 201410112433.6, 2015年授权.

5. 赵春建, 李春英, 付玉杰, 祖元刚.一种促进喜树生长和喜树碱含量增加的方法(发明专利), 专利号:ZL 201410122275.2, 2015年授权.

6. 赵春建, 李春英, 付玉杰, 祖元刚.一种促进小叶杨生长的方法(发明专利), 专利号:ZL 201410122212.7, 2015年授权.

7. 赵春建, 李春英, 祖元刚.一种植物挥发物原位收集装置(实用新型), 专利号:201420160255.X, 2014年授权.

8. 赵春建, 李春英, 祖元刚. 双层结构的植物根系分泌物收集盒(实用新型), 专利号::201420147062.0, 2014年授权.

9. 李春英,赵春建,祖元刚. 一种从烟草中提取辅酶Q10的方法(发明专利), 专利号:ZL 201110289097.9, 2014年授权.

10. 李春英, 赵春建, 付玉杰, 苏伟然, 李玉正, 关佳晶. 红豆杉和无花果树混交林的营造方法, ZL 202010406489.8, 2021年授权.

11. Chunying Li, Chunjian zhao, Yujie Fu, Weiran Su, Yuzheng Li, Jiajing Guan. Method for constructing a mixed forest of yew trees and fig trees, US17/297 204, 2022年授权.

12. 祖元刚, 赵春建, 李春英, 祖柏实, 付玉杰, 赵修华, 张颜滨, 张军. 一种辅酶Q10生产原料的加工方法(发明专利), 专利号:ZL 200610009696.X, 2008年授权.

13. 祖元刚, 赵春建, 付玉杰, 李春英, 祖柏实, 李庆勇, 李雪莹, 焦琰. 一种从烟叶中提取纯化茄尼醇的方法(发明专利), 专利号:ZL200410013561.1,2006年授权.

14. 祖元刚, 史权, 赵春建, 祖柏实. 促进喜树种子芽内10-羟基喜树碱生成的方法(发明专利), 专利号:ZL02132922.2, 2004年授权.

15. 祖元刚, 杨磊, 张琳, 赵春建, 祖柏实, 高敏, 隋小宇, 夏禄华, 李家磊, 肖长文. 一种以马铃薯叶为原料制备高纯度茄尼醇的方法. ZL 200610010591.6, 2010年授权.

16. 祖元刚, 唐中华, 付玉杰, 张宝友, 李庆勇, 赵春建, 史权一种10-羟基喜树碱和喜树碱的生产原料的加工方法(发明专利), 专利号:ZL02132410.7, 2004年授权.

17. 祖元刚, 李庆勇, 付玉杰, 张宝友, 李春英, 赵春建, 王化田. 用刺五加生产异嗪皮定、刺五加甙、刺五加多糖的方法(发明专利), 专利号:ZL 02109475.6, 2005年授权.

18. 祖元刚, 史权, 祖柏实, 付玉杰, 张宝友, 赵春建, 刘士刚 喜树碱高效生产工艺, 发明专利 ZL02132721.1, 2004年授权.


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